Owing to its special composition, Burgimmune is expressly indicated for use in the adjuvant therapy of tumour diseases, as a food supplement.It supports the non-specific humoral and cellular immune response, increases the success rate of antitumour therapies and, at the same time, minimises their adverse effects.
Immunoenhancer
Antitumour effect
Antioxidant
Antitumour effect
Supports the health of the skin
Faster regeneration
More effective vaccination
Appetite stimulant, antiemetic
Haematopoiesis-enhancing
BETA-GLUCANS:
Beta-glucans are complex carbohydrate molecules with unique molecular structure that determines their biological activity. These substances, having a branched structure at their 1,3 and 1,6carbon atoms, belong to the best known immunostimulants. These molecules with a branched structure at the 1,3 and 1,6 carbon atoms are derived from the cell wall of yeasts and treated with a special procedure to achieve the strongest immunological activity.Numerous clinical studies have demonstrated that beta-glucans extracted from yeast cell wall have the strongest immunological effects. They effectively support the immune system in the fight against bacteria and viruses, and they improve the efficiency of vaccination.
It has been demonstrated that the level of antibodies to canine parvovirus and rabies virus substantially increased in dogs that received beta-glucan simultaneously with the vaccination (Haladová et al., 2011). When administered orally, beta-glucans increase the levels of IgG and IgA antibodies in the blood and on the mucous membranes. The mechanism of action of beta-glucans is based on specific receptors located on macrophages, neutrophils, monocytes, dendritic cells and natural killer (NK) lymphocytes (Stuyven et al., 2010).Beta-glucans activate the complement system and stimulate the production of pro- and anti-inflammatory interleukins (IL-1, IL-6, IL-10, IL-12) and TNF-α, thus increasing the stability of the immune system and protecting the body against bacterial, viral, fungal and parasitic infections (Pelizon et al., 2005; Wójcik et al., 2007; Chen and Seviour, 2007). The main role of beta-glucans is to activate macrophages, which are immune cells constituting the first line of defence of the immune system.
The macrophages ‘digest’ beta-glucan and the active fragments thus released bind to the complement receptors of neutrophil granulocytes, thereby activating the pathogen destruction mechanism.The antitumour activity of beta-glucan is based on its activation of the complement receptors of neutrophil granulocytes, which enables these cells to recognise and destroy tumour cells.
CORIOLUS VERSICOLOR
(TURKEY TAIL) MUSHROOM:
Coriolus versicolor (also known as Trametes versicolor, Polyporus versicolor, turkey tail or Yun Zhi) is a common mushroom species found all over the world. The name ‘versicolor’ reflects that this fungus displays different colours.The active substances of this mushroom support the generation and activity of natural killer (NK) cells which help kill tumour cells and overcome infections.In some countries the turkey tail mushroom is regularly cultivated to produce natural polysaccharides, beta-glucan (PSK) and polysaccharide peptide (PSP). The medicines made from these polysaccharides are used as an adjuvant therapy in cancer patients to supplement surgery, radiotherapy and chemotherapy and to reduce their adverse effects. PSK is a widely used antitumour medicine in Japan.In addition to reducing the unfavourable effects of conventional antitumour therapies, the mushroom extract also has a beneficial effect on the immune system
In a study recently conducted at the College of Veterinary Medicine of Pennsylvania State University, dogs suffering from haemangiosarcoma were treated with a compound extracted from the mushroom Coriolus versicolor. Based on the criteria studied by the researchers, i.e. the speed of tumour growth and/or spread and the length of the dogs’ survival, the results showed that this fungal product was effective against the tumour, increasing the average survival time to 199 days, while previously the longest survival time had been only 86 days.
The active substances of Coriolus versicolor are beta-glucan–protein complexes (PSK, krestin) which have antioxidant, antitumour, antiviral and immunomodulant effects. The direct antitumour activity of the PSK polysaccharide has been proved experimentally.The other important active substance is the polysaccharide peptide (PSP), which also has antiviral and antioxidant effects. Ergosterols (D29-provitamin derivatives) are polysaccharide compounds having antitumour effect.PSK and PSP are the most important active substances of the Coriolus versicolor fungus.Both compounds support the functioning of the immune system in many different ways. Ergosterols reduce the growth of tumours and the formation of metastases by inhibiting vascularisation.
GINSENG:
SPIRULINA ALGA:
VITAMIN B6:
VITAMIN E:
